HDAC11: The Lone Mystic Member of Class IV HDAC

Arunasree M Kalle; Shikha Raina

doi:10.16943/ptinsa/2019/49577

Arunasree M Kalle University of Hyderabad
Shikha Raina University of Hyderabad

DOI: https://doi.org/10.16943/ptinsa/2019/49577

Keywords: HDAC11, repressor complex, cell survival

Abstract

Histone deacetylases (HDACs) are the members of Histone deacetylase superfamily and are known to play an important role in histone modification and thereby regulating gene transcription. In humans, the 18 HDACs are divided into four classes, namely Class I to IV. Among the four classes of HDACs, Class IV has a single member, HDAC11. Although few reports indicate the physiological role of HDAC11 in immune tolerance via the regulation of IL10 production, its role in relation to the cellular physiology remains unexplored. According to Cancer Atlas database, HDAC11 shows high mutations in many cancer patients and thereby acting as a potential candidate for targeted drug therapy. Due to the overlapping functions between the HDAC isoforms belonging to various classes, several toxicities are reported with HDAC inhibitors in clinical trials. However, HDAC11 being the only member of class IV is unique and a potent drug target for carcinomas. In this review, we summarize the existing knowledge on HDAC11.

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